Metastatic Colonization: Escaping Immune Surveillance
نویسندگان
چکیده
منابع مشابه
Prediction of immune surveillance responsive metastatic prostate cancer in pelvic lymph node and emergence of surveillance unresponsive/resistant metastatic cells.
BACKGROUND Immune cells (lymphocytes and macrophages) provide the microenvironment for immune surveillance of metastatic prostate cancer (PCa) cells in pelvic lymph nodes. We have hypothesized that degeneration and/or apoptosis of metastatic PCa cells in pelvic lymph nodes can distinguish between aggressive and non-aggressive metastatic disease in patients. Our objective was to define the relat...
متن کاملEscaping Deleterious Immune Response in Their Hosts: Lessons from Trypanosomatids
The Trypanosomatidae family includes the genera Trypanosoma and Leishmania, protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and an insect vector. Trypanosoma brucei gambiense, Trypanosoma cruzi, and Leishmania spp. are important human pathogens causing human African trypanosomiasis (HAT or sleeping sickness), Chagas' disease, and various clinical forms o...
متن کاملImmune surveillance of tumors.
The ability of the immune system to identify and destroy nascent tumors, and to thereby function as a primary defense against cancer, has been debated for many decades. Recent findings by a number of investigators in both mouse models of cancer and humans with cancer now offer compelling evidence that particular immune cell types, effector molecules, and pathways can sometimes collectively func...
متن کاملPD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance.
The prognosis of high-risk neuroblastoma (NB) remains poor, although immunotherapies with anti-GD2 antibodies have been reported to provide some benefit. Immunotherapies can be associated with an IFNγ storm that induces in tumor cells the "adaptive immune resistance" characterized by the de-novo expression of Programmed Death Ligands (PD-Ls). Tumor cells can also constitutively express PD-Ls in...
متن کاملSensing hyperploidy and immune surveillance
542 Cell Cycle Volume 12 Issue 4 Our life starts with the fusion of oocytes with spermatozoa, eventually leading to the development of an embryo. Though the cellular events involved in fertilization are welldescribed, their molecular underpinnings remain poorly understood.1 Substances controlling the elementary fusion processes are of utmost socioeconomic and medical relevance. Spermidine is a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancers
سال: 2020
ISSN: 2072-6694
DOI: 10.3390/cancers12113385